Stem cells to help treat bowel cancer

Stem cell scientists have developed a new and more accurate way of spotting aggressive forms of bowel cancer, allowing for tailored treatment that should improve patients' chances of survival.

British researchers said on Wednesday those with the most aggressive kind of cancer could be identified early by testing for a stem cell marker protein called Lamin A.

The team concluded that patients testing positive for Lamin A should be given chemotherapy, in addition to surgery, to increase their chances of survival.

The discovery is the latest example of new tests being developed that can help doctors decide how and when to treat different manifestations of cancer.

In the two earliest of the four key stages of bowel cancer, patients normally have an operation to remove their tumor but are rarely given chemotherapy, since the toxic treatment can cause more harm than good.

The new research, however, suggests that around one third of these early-stage patients will have the Lamin A stem cell marker, indicating a more serious form of disease, and they are likely to benefit from chemotherapy.

"Chemotherapy can be very useful but can have a number of side effects, so we only want to use it where we think there's a good chance it will help. This test will help us determine that," said Robert Wilson, a bowel cancer specialist at The James Cook University Hospital, Middlesbrough.

The team from Durham University and the North East England Stem Cell Institute now aims to develop a robust prognostic tool that eventually can be used widely in hospitals.

Their research was published in the Public Library of Science journal PLOS One and is available online here

For more information visit http://www.jigfo.com, the no.1 source of information.

Stem cells can be grown into nerve cells

Ordinary skin cells taken from patients with a fatal and incurable nerve disease have been transformed into nerve cells in a first step toward treating them, U.S. researchers reported on Thursday.

They transformed the cells from two patients with amyotrophic lateral sclerosis, or Lou Gehrig's disease, into motor neurons -- the cells that waste away and die in ALS.

There is no immediate medical use for the cells, taken from two sisters aged 82 and 89, the researchers reported in the journal Science.

"Now we can make limitless supplies of the cells that die in this awful disease. This will allow us to study these neurons, and ALS, in a lab dish, and figure out what's happening in the disease process," said Dr. Kevin Eggan of Harvard Medical School in Boston, who helped lead the study.

"We can generate hundreds of millions of motor neurons that are genetically identical to a patient's own neurons," added Chris Henderson of Columbia University in New York, who also worked on the study.

"This will be an immense help as we try to uncover the mechanisms behind this disease and screen for drugs that can prolong life."

There is no cure for ALS, also called motor neuron disease or Lou Gehrig's disease after the New York Yankees baseball player who died of it in 1941. The causes are not clear and it kills by gradually paralyzing patients.

About 120,000 new cases are diagnosed each year, according to the International Alliance of ALS.

"It is our lack of understanding of that disease process which is preventing us from developing more effective (treatments)," Henderson told reporters in a telephone briefing.

"There is no way we could go to an ALS patient and take a sample of their motor neurons," he added, because the affected cells are in the spinal cord.

DISEASE IN A DISH

Eggan and Henderson hope to grow and study these motor neurons and see if they can re-create the disease in a lab dish -- and then try out various drugs to treat it.

The two patients have a mild form of ALS caused by a single genetic mutation, and all of the cells in their body carry that mutation.

The experiment helps fulfill one of the promises of embryonic stem cell research, Eggan said. The hope of the controversial research has always been to figure out ways to make ordinary cells into customized scientific experiments, and into tailor-made medical treatments.

Last year several teams of researchers reported they had genetically engineered ordinary skin cells to act like embryonic stem cells -- the master cells of the body, which have the ability to morph into any cell or tissue type.

Eggan said this does not mean it is no longer necessary to use the controversial methods to get real embryonic stem cells by using human embryos from fertility clinics or by using cloning technology.

For one thing, they used viruses to carry in the four genes that transformed the skin cells. These viruses integrate into the cells, making them far too dangerous to use in people, Eggan said.

For another, the genetic defect that causes ALS would have to be corrected before the cells could be used in any treatment, the researchers said.

Embryonic stem cell research is what allowed them to figure out how to do every step in their experiment, Eggan added. And if this one fails, the researchers will have to return to true embryonic stem cells.

For more information visit http://www.jigfo.com, the no.1 source of information.